Syndicate is a reboot of the Bullfrog strategy series franchise from the nineties. Unlike the original games where the focus was on tactical management of a shooter squad, this version is a first-person shooter set in the same universe but without strategy elements.

The game takes place in 2069 in a world that is ruled by syndicates following the invention of a neural chip implant that gives users direct access to a dataverse network without the use of electronic devices. Due to this technical revolution, the world has been divided between chipped and unchipped people, where the latter refuse and oppose the advancement. There is tension between the different syndicates as well, with lots of corporate espionage. Syndicates battle his by deploying bio-engineered agents that are enforced with chips. They defend the intelligence of their own syndicate and attempt to infiltrate others. Players take command of Miles Kilo, an agent of the Eurocorp syndicate. He has a new prototype chip and is sent out on a mission to test the abilities. The events of this first mission set in motion the storyline for the rest of the game, filled with espionage, betrayal, brutal murders and the opposition of unchipped civilians who are deemed terrorists.