Worms Reloaded is the first traditional 2D entry in the Worms series for the PC since Worms World Party and incorporates some of the new ideas in the versions since released on the Nintendo DS and Xbox 360.

The game's core game play is still identical, but many new features have been added or upgraded since previous releases. In either single player or multi player two to four teams of up to four worms per team duke it out in turn-based combat. Using a variety of weapons players attack each other in what is essentially a more complex version of the classic Artillery. Player's can lob grenades, fire rocket launchers, drop mines, fire guns or use many of the wacky fictional weapons such as Monty Python's holy hand grenade or exploding sheep. The terrain is fully destructible and surrounded by water. Worms can't swim so when they are thrown in the water by an explosion it's an instant kill. There are also various hazards present on the terrain such as the familiar mines and oil barrels (that put the terrain on fire), but also new hazards such as sentry guns.

The game features an all new single player campaign with 35 levels, an advanced campaign with 30 levels and an additional 5 unlockable levels. Finishing levels earns money which can be used to buy these new levels, new weapons, themes, hats, etc. Using Steamworks the game has an automatic match making system and online matches are ranked in the global and friends leader boards. Players can control up to four worms per team with up to four teams per match. There's also a selection of achievements which can be unlocked as is usual with games released on Steam.

Worms are fully customizable, including colour, hat, gravestone, victory dance, names, fort (for the fort game mode) and soundbank. All soundbanks of earlier Worms games are included with the addition of 20 new ones. Levels are also fully customizable. A simple drawing program allows the player to draw his own levels and simply apply a skin and automatically fill it up with hazards and worms, or carefully determine the exact position of everything manually. Levels can now also easily be made more vertical, for those who aren't afraid of some steep heights.