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Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.
Profiles paraneoplastic diseases by tumor typeIdentifies the pathogenetic mechanisms of PNS and provides epidemiological analysisPresents individual syndromes of the CNS, PNS, NMJ, and muscleInvestigates the role of antibody markersDifferentiates cytoplasmic, nuclear, and neuronal cell surface reactivitiesDiscusses immune-oncological drugs causing diseases that are indistinguishable from PNSReviews therapeutic strategies and clinical approach to PNS patients
Introduction and Overview
Introduction and overview of immunopathological mechanisms and future directions
Changing landscape in the field of paraneoplastic neurology: Personal Perspectives over a 35-year career
Pathogenesis and immunopathology of paraneoplastic disorders
Paraneoplastic neurological syndromes
Epidemiology of paraneoplastic neurologic syndromes
Clinical approach to diagnosis of paraneoplastic neurological syndromes
Overview of treatment strategies in paraneoplastic neurological syndromes
Methods to Detect Paraneoplastic Antibodies
Paraneoplastic encephalitis
Autoimmune and paraneoplastic seizures
Paraneoplastic Cerebellar and Brainstem Disorders
Paraneoplastic/autoimmune myelopathies
Paraneoplastic vision loss
Paraneoplastic movement disorders
Movement disorders associated with pediatric encephalitis
Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders
Paraneoplastic autonomic neuropathies and GI dysmotility
Myasthenia Gravis – Pathophysiology, diagnosis and treatment
Lambert-Eaton myasthenic syndrome
Paraneoplastic myopathies
Paraneoplastic autoantibodies
Intracellular paraneoplastic autoantibodies
Antibodies to neural cell surface and synaptic proteins in paraneoplastic neurologic syndromes
Optimizing the diagnostic performance of neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practice
Paraneoplastic neurological and autoantibody accompaniments of cancer
Paraneoplastic Autoimmune Neurological Disorders associated with Thymoma
Paraneoplastic Neurologic Manifestations of Neuroendocrine tumors
Paraneoplastic Neurological Syndrome associated with Gynaecological and Breast malignancies
Hematological malignancies and hematopoietic stem cell transplantation
Paraneoplastic neurological syndrome and autoantibody accompaniments of germ cell tumors
Neurological complications of cancer immunotherapy
Neurological manifestations of autoimmunity with immune checkpoint inhibitors