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This textbook introduces the clinical applications of biomolecules in disease diagnosis, covering a range of topics in biochemistry. The book discusses carbohydrate and protein metabolism abnormalities, lipid digestion and absorption defects, disorders of purine and pyrimidine metabolism, and the chemistry and biological roles of water- and fat-soluble vitamins. It also covers the roles of different macroelements and essential trace elements in physiological processes and the prevention of chronic diseases. The final chapter focuses on recent developments in our understanding of the role of enzymes in disease development and diagnosis. The book chapter also explores the causes and effects of free radicals in the body, including oxidative stress and diseases such as cardiovascular and neurodegenerative diseases. Finally, the chapter discusses cancer development, causes, diagnosis methods, biomarkers, and current treatments such as targeted drug therapy, chemotherapy, and radiation therapy. This book is a useful resource for undergraduate and postgraduate students, researchers and practitioners in biochemistry, medicine, and health sciences.
Front Matter
Introduction to Clinical Applications of Biomolecules in Disease Diagnosis
Carbohydrate Metabolism in Health and Diseases
Protein Metabolism and Its Profiling for the Diagnosis of Metabolic Disorders
Disorders of Lipid Metabolism
Nucleic Acid Metabolism and Disorders
Vitamins and Their Impact on Human Health
Electrolytes and Acid-Base Disorders
Metabolism of Macro-elements (Calcium, Magnesium, Sodium, Potassium, Chloride and Phosphorus) and Associated Disorders
Metabolism of Essential Trace Elements and Associated Disorders
Enzymes and Their Clinical Applications
Hormonal Manifestations of Endocrine Diseases
Biomolecular Components of Blood and Their Role in Health and Diseases
Free Radicals and Their Relation to Diseases and Protection Against Them
Clinical Biochemistry of Cancer
Outbreak of Deadly Coronavirus (COVID-19) Pandemic: Diagnosis and Management
Techniques for the Identification and Characterization of Biomolecules