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In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.
The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.
This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.
- Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy.
- Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID.
- Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases.
- Supplemented with a website that hosts a Podcast per chapter.
Immunologic Basis of Autoimmunity
Prelude: Historical introduction to autoimmunity and autoimmune disease
Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity
General Features of Autoimmune Diseases (same title new contributor, new content)
Antigen Presentation, Dendritic Cells, and Autoimmunity
T cells and their subsets
Role of Th1 Th2 Th17 Cells in Autoimmunity
Tolerance and Autoimmunity: T Cells
Regulatory T Cells
B Cells and Autoimmunity
Immunological memory T cells
Immunological memory B cells
Apoptotic Cells as a Source of Autoantigens
Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes
Functional Effects of Autoantibodies
Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes
HLA Genetics and Autoimmunity
Non HLA Genetics
AIRE related Autoimmunity
Immune Deficiencies and Autoimmunity
Infections and Autoimmunity
Noninfectious Environmental Agents and Autoimmunity
Sex, Pregnancy and Autoimmunity
Animal Models of Autoimmune Disease
Multisystem Diseases
Systemic Lupus Erythematosus
Systemic Sclerosis, Scleroderma
Antiphospholipid Syndrom
Sjogren Syndrome
Rheumatoid Arthritis
Spondyloarthritis and Chronic Idiopathic Arthropathies
Myositis
Thyroid Disease
Type 1 Diabetes
Adrenalitis
Polyendocrine Syndromes
Gastritis and Pernicious Anemia
Hypophysitis
Hemolytic Anemia
Thrombocytopenic Purpura
Neutropenia
Aplastic Anemia
Clotting Disorders
Multiple Sclerosis
Peripheral Neuropathy
Myasthenia Gravis
Ocular Disease
Inner Ear Disease
Celiac Disease
Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease
Chronic Hepatitis
Primary Billiary Cirrhosis
Primary Sclerosing Cholangitis
Pancreatitis
Bullous Skin Diseases: Pemphigus and Pemphigoid
Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria
Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis
Orchitis and Male Infertility
Oophoritis
Rheumatic Heart Disease
Myocarditis and Dilated Cardiomyopathy
Necrotizing Arteritis and Small Vessel Vasculitis
Large and Medium Vessel Vasculitides
Autoimmune Disorders of the Lung
Paraneoplastic Diseases
Antibody-Associated Neurological Diseases
Autoinflammatory and other Related Diseases
Autoinflammatory diseases and autoimmune responses to tumors
COVID
Diagnosis, Prevention, and Therapy
Autoantibody Assays, Testing, and Standardization
Prediction of Autoimmune Disease
Emerging Therapies for Autoimmune Diseases
Postlude