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Completely revised and updated, this fourth edition elucidates the principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery.
With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Consequently, this edition of the book emphasizes the heightened focus that the recent remarkable progress in gene editing, immunotherapy, and nanotechnology has brought to the design of new drugs and diagnostic approaches along with novel dosage forms.
Apart from new chapters, this edition highlights the emerging emphasis on the role of artificial intelligence (AI) in drug discovery, mRNA and antibody-based therapies, genome editing, immunotherapy, chemical kinetics, and the stability of drug products.
Features:
Includes new chapters on antibody therapeutics, gene editing, and immunotherapy.
Explains newer approaches and future methods and the significance of artificial intelligence (AI) in drug discovery.
Updated sections on pharmacy mathematics, chemical kinetics, and the stability of medicinal products.
Important updates on parenteral drug products, protein and peptide treatments, and biotechnology-based pharmaceuticals to provide a contemporary perspective on drug development, delivery, and pharmaceutical sciences.
Expansion of review questions and answers to clarify concepts for students and add to their grasp of key concepts covered in this book.
Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors, and professionals, saving their time and money.
Dedication
Foreword
Preface
About the Authors
Introductory Chapters
Drug Discovery
Drug Development
Pharmaceutical Considerations
Biopharmaceutical Considerations
Pharmacy Math and Statistics
Physicochemical Principles
Complexation and Protein Binding
Chemical Kinetics and Stability
Interfacial Phenomena
Colloidal Dispersions
Surfactants and Micelles
Pharmaceutical Polymers
Rheology
Radiopharmaceuticals
Drug Delivery Systems
Organ-Specific Drug Delivery
Dosage Forms
Suspensions
Emulsions
Pharmaceutical Solutions
Powders and Granules
Tablets
Capsules
Parenteral Drug Products
Semisolid Dosage Forms
Inserts, Implants, and Devices
Pharmaceutical Biotechnology
Protein and Peptide Drug Delivery
Antibody Therapeutics
Biotechnology-Based Drugs
Genome Editing for Therapeutic Applications
Immunotherapy
Answers to Review Questions
Index