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The book delves into the intricate realm of pharmacokinetics and pharmacodynamics as they apply to modern advancements in drug delivery systems. It offers a comprehensive exploration of novel drug delivery methods, with a particular focus on nanoparticles and nanocarriers. The absorption, distribution, metabolism, and excretion processes of nanoparticles are extensively examined. It also covers various evaluation models, spanning from preclinical to clinical, aimed at assessing the effectiveness and safety of nanoparticles in drug delivery.
It also covers the integration of Artificial Intelligence and Machine Learning in pharmacokinetics and pharmacodynamics, showcasing how these cutting-edge approaches can enhance our understanding of drug behavior and optimize therapeutic outcomes. It serves as a comprehensive guide, highlighting the fusion of traditional pharmacological concepts with contemporary drug delivery systems and innovative technologies, all in the pursuit of refining medical treatments and patient care and is a valuable resource for academicians, researchers, and pharmacologists.
Preface
Disclaimer
About the Editors
Introduction to Pharmacokinetics and Pharmacodynamic Studies of Novel Drug Delivery Systems
Introduction
Regulatory Guidelines for NDDS in Pharmaceutical Industry
Need of Pharmacokinetic and Pharmacodynamic Studies (PK/PD) of NDDS
Conclusion
Bibliography
Absorption, Distribution, Metabolism and Excretion of Novel Drug Delivery Systems
Physicochemical Properties Affecting ADME of Novel Drug Delivery Systems
Effect of Surface Modification on ADME of Nanoparticles
Effect of Patient Related Factors on ADME of Novel Drugs and Novel Drug Delivery Systems
Biodistribution of Novel Drugs and Nanoparticles in Solid Tumors
Bibliography
Pharmacokinetic, Pharmacodynamic, Preclinical and Clinical Models for Evaluation of Nanoparticles
Pharmacokinetic (PK) Model
Compartmental Modeling
Noncompartmental Modeling
Pharmacodynamic (PD) Model
Nonlinear Mixed-Effects (NLME) Model
Preclinical Model
Dermatopharmacokinetic Model
Clinical Model
Bibliography
Pharmacokinetics and Pharmacodynamics of Nanocarriers and Novel Drug Delivery Systems
Pharmacokinetics and Pharmacodynamics of Polymeric Nanoparticles
Pharmacokinetics and Pharmacodynamics of Lipid Based Nanocarriers
Pharmacokinetics and Pharmacodynamics of Vesicular Nanocarriers
Pharmacokinetics and Pharmacodynamics of Metallic Nanocarriers
Pharmacokinetics and Pharmacodynamics of Implants
Pharmacokinetics and Pharmacodynamics of Topically Administered Novel Drug Delivery Systems
Bibliography
Clinical Applications of Pharmacokinetic and Pharmacodynamic Studies of Targeted Novel Drug Delivery Systems
Targeted Delivery to Central Nervous System and Brain
Targeted Delivery to Respiratory System
Targeted Delivery in Cancer
Targeted Delivery to the Eye
Targeted Delivery of Biomolecules and Gene Therapy
Bibliography
Artificial Intelligence and Machine Learning in Pharmacokinetics and Pharmacodynamic Studies
In-Silico Approach for Predicting PK/PD: In Vitro-In Vivo Extrapolation (IVIVE)
AI/ML Based Software/Tools for Predicting PK/PD
Applications of AI/ ML in PK/PD
Bibliography