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This volume provides readers with an overview of translational paths that can be used to study the pathophysiology of Parkinson’s Disease and atypical parkinsonism, including molecular processes, tissue integrity, and cerebral networks during inflammatory and neurodegenerative processes. The chapters in this book are organized into three parts and cover topics such as new developments of cerebral circuit characterizations and computational neuroscience for the description of the brain’s transition through disease stages static and dynamic systemic changes with clinical and functional outcome measures and atypical syndromes such as neurodegenerations, immunological processes, and progressive disease states. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Translational Methods for Parkinson’s Disease and Atypical Parkinsonism Research is a valuable resource that provides a new perspective on the disease from a scientific and clinical point of view, and highlights the importance of available and emerging technologies.
Dedication
Preface
Preface to the Series
Contributors
Pathophysiology and Pathology in Parkinson´s Disease and Atypical Parkinsonism
Pathophysiological Basis of Neurodegeneration in Parkinson´s Disease
The Role of Alpha-Synuclein Pathology
Crosstalk Between the Immune and Nervous Systems
Role of Microglia in Parkinson´s Disease Pathology
Toxin-Induced Rodent Models of Parkinson´s Disease
Selected Clinical and Diagnostic Aspects Non-motor Features in Parkinson´s Disease
Studying Neuropsychiatric Symptoms, Depression, Anxiety in Parkinson´s Disease
Memory Deficits and Their Neuronal Substrates in Idiopathic Parkinson´s Disease
Translational Value of CSF and Serum Markers
The Use of Next-Generation Sequencing in Diagnosing Inherited Atypical Parkinsonian Disorders
Measuring Functional Impairments Using Novel Technologies
Exploring Translational Paths in Parkinson´s Disease and Atypical Parkinsonism with Human Structural MRI
A Practical Guide to Metabolic and Molecular Imaging in Atypical Parkinsonism
Network Vulnerability in Parkinson´s Disease
Exploring Translational Paths in Parkinson´s Disease Studies with Invasive Electrophysiology
Non-invasive Neurostimulation Studies in Parkinson´s Disease
Deep Brain Stimulation as a Tool to Study the Neural Basis of Decision-Making and Motor Control in Parkinson´s Dis...
A Glimpse into the Future
Translational View on Therapeutic Strategies and Upcoming Issues: Stem Cell and Brain Organoid Approaches for Park...
Translating Therapeutic Strategies for Genetic Parkinson´s Disease Syndromes
Index