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The Frontal Lobes updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more. Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.
Foreword
Preface
Contributors
History
The prefrontal cortex in the neurology clinic
Methods
The functions of the frontal lobes: Evidence from patients with focal brain damage
Cognitive neurophysiology of the prefrontal cortex
Functional imaging
Transcranial magnetic stimulation: Neurophysiological and clinical applications
Anatomy, physiology and pharmacology
The anatomy of the human frontal lobe
Dopamine and the motivation of cognitive control
Function of the frontal lobes
Frontal lobe syndromes
Hierarchical cognitive control and the frontal lobes
Hemispheric asymmetry in the prefrontal cortex for complex cognition
Executive functions
The lateral prefrontal cortex and human long-term memory
From ideas to action: The prefrontal–premotor connections that shape motor behavior
Emotion regulation across the life span
Reward
Moral conduct and social behavior
Computational models of motivated frontal function
Control networks of the frontal lobes
Development, aging, and disorders
Development of the frontal lobe
Aging of the frontal lobe
Neurodegenerative disorders of the human frontal lobes
Traumatic brain injury and frontal lobe plasticity
Rehabilitation
Strengthening goal-directed functioning after traumatic brain injury
Experimental social training methods
Plasticity and recovery of function