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This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
Preface
Organization of the Book
Acknowledgments
About the Author
Introduction to Cell Signaling Pathways and Brain Tumors
Wnt Cell Signaling Pathway in Brain Tumor Development
Notch Cell Signaling Pathway and Brain Tumors
Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma
Role of the Shh Signaling Pathway in the Most Common Brain Tumor “Glioma” role in Glioma Growth
NANOG Stem Cell Marker and Its Role in Brain Tumor Development
Stem Cell Factor Sox2 and Brain Tumor Development
Role of Neurotrophins in Brain Tumor Development
Role of NF-kB in Brain Tumor Development
Role of Myc in Brain Tumor Development
Role of p53 in Medulloblastoma Development
Role of TP53 Gene in Glioma
Role of HIF-1 in Brain Tumor Development
EGFR and Its Role in Glioma Development
Role of EFGR in Medulloblastoma Development
Role of OCT4 in Glioblastoma
Role of OCT4 in Pediatric Brain Tumor “Medulloblastoma” Development
Mitogen-activated protein (MAP) kinase Roles in Paediatric Brain Tumor “Medulloblastoma”