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This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.
Acknowledgments
Introduction
Lipid Metabolism and Lipidomics Applications in Cancer Research
Applications of Lipidomics in Tumor Diagnosis and Therapy
Overview: Lipid Metabolism in the Tumor Microenvironment
Lipid Metabolism in Cancer Cells
Lipid Metabolism in Tumor-Associated Natural Killer Cells
Lipid Metabolism in Tumor-Associated Macrophages
Lipid Metabolism in Tumor-Associated Myeloid-Derived Suppressor Cells
Lipid Metabolism in Tumor-Associated Fibroblasts
Lipid Metabolism in Tumor-Associated B Cells
Lipid Metabolism in Tumor-Infiltrating T Cells
Lipid Metabolism and Tumor Antigen Presentation
Lipid Metabolism and Immune Checkpoints