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Optimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative.
The volume, which includes new methods as well as review contributions will benefit awide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.
Preface
Contributors
Process Control and Intensification of Solution Crystallization
Method of Characteristics for the Efficient Simulation of Population Balance Models
Linearized Parameter Estimation Methods for Modeled Crystallization Phenomena Using In-Line Measurements and Their Application to Optimization of Partially Seeded Crystallization in Pharmaceutical Processes
Mathematical Modeling of Different Breakage PBE Kernels Using Monte Carlo Simulation Results
Optimization of Tablet Coating
Continuous Twin-Screw Granulation Processing
Continuous Powder Feeding: Equipment Design and Material Considerations
Ultrasound for Improved Encapsulation and Crystallization with Focus on Pharmaceutical Applications
Nonsmooth Modeling for Simulation and Optimization of Continuous Pharmaceutical Manufacturing Processes
Integrated Synthesis, Crystallization, Filtration, and Drying of Active Pharmaceutical Ingredients: A Model-Based Digital Design Framework for Process Optimization and Control
Fast Model Predictive Control of Modular Systems for Continuous Manufacturing of Pharmaceuticals
Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant
Overview of Scheduling Methods for Pharmaceutical Production
Model-Based Risk Assessment of mAb Developability
Design Framework and Tools for Solid Drug Product Manufacturing Processes
Challenges and Solutions in Drug Product Process Development from a Material Science Perspective