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A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.
This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.
Foreword
Preface
Introduction
Modelling of PK/PD for NPDDS
Introduction to Nanoparticulate Drug Delivery Systems
Nanoparticle Properties Affecting the Drug Release, Absorption, and Pharmacokinetics of Nanoparticulate Drug Delivery Systems
Models Used for Biopharmaceutical Evaluation of Nanoparticulate Drug Delivery System (NPDDS)
Models Used for Pharmacokinetic Evaluation of Nanoparticulate Drug Delivery Systems (NPDDS)
Models Used in Pharmacodynamic Evaluation of Nanoparticulate Drug Delivery Systems (NPDDS)
Preclinical Animal Models for the Experimental Design of Pharmacokinetic Studies with Nanoparticulate Drug Delivery Systems
Pharmacokinetic Modeling Program (PKMP): A Software for PK/PD Data Analysis
PK/PD for Specific Nano Carriers
Pharmacokinetics and Pharmacodynamics of Liposomal Nanoparticles
Pharmacokinetics of Drug-in-Polymer Matrix-Based Nanoparticulate Drug Delivery System
Pharmacokinetics of Long Circulating Inorganic Nanoparticulate Drug Delivery Systems
Metallic Gold Nanoparticles: In Vivo Pharmacokinetics and X-Ray Contrast Imaging Studies
Mucoadhesive Nanoparticulate Drug Delivery System (NPDDS): In Vitro and Pharmacokinetic Studies
Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
PKPD of PLGA-PEG-PLGA Copolymeric Micelles
PKPD in Diseased Conditions for NPDDS
Bridging Bio-Nanoscience and Cancer Nanomedicine
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles for Diagnostics
PLGA Nanoparticles for Oral Delivery: Nephrotoxicity and Pharmacokinetic Studies
Pharmacokinetics of Nanoparticle Systems for Pulmonary Delivery
In Vivo Biodistribution and Pharmacokinetic Studies of NPDDS for Brain Targeting
Enhanced Bioavailability and Intestinal Uptake of Nanoparticles After Oral Delivery
Nanoparticle Pharmacokinetic Profiling In Vivo Using Magnetic Resonance Imaging
Index