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Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated.
Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.
Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.
Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies.
Illustrates the impact of molecular research on hematologic investigations and therapeutics.
Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders.
Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma.
Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools.
Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.
List of contributors.
Foreword.
Preface.
Beginnings: the molecular pathology of hemoglobin.
Douglas Higgs and Mohsin Badat.
Stem cells.
David T. Scadden.
The genetics of acute myeloid leukemia.
Amye M. Harrigan and Amy M. Trottier.
Molecular diagnostics and risk assessment in myeloid malignancies.
Christian Scharenberg and Torsten Haferlach.
Molecular basis of acute lymphoblastic leukemia.
Shunsuke Kimura and Charles G. Mullighan.
Chronic myelogenous leukemia.
Hagop Kantarjian, Elias Jabbour and Susan O’Brien.
Myeloproliferative neoplasms.
Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan.
Lymphoma genetics.
Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi.
Molecular basis of chronic lymphocytic leukemia.
Bita Fakhri and Alexey Danilov.
The molecular biology of multiple myeloma.
Udit Yadav and Wilson I. Gonsalves.
The molecular basis of bone marrow failure syndromes and red cell enzymopathies.
Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris.
Anemia of chronic disease.
Tomas Ganz and Elizabeta Nemeth.
Molecular basis of iron metabolism.
Jodie L. Babitt and Tomas Ganz.
Perspectives in genomics and sickle cell disease therapeutics.
Ambroise Wonkam.
Molecular coagulation and thrombophilia.
Björn Dahlbäck and Andreas Hillarp.
The molecular basis of hemophilia.
Keith Gomez.
The molecular basis of von Willebrand disease.
Omid Seidizadeh and Luciano Baronciani.
Platelet disorders.
Kenneth J. Clemetson.
The molecular basis of blood cell alloantigens.
Winnie Chong, Louise Tilley and Colin Brown.
Functions of blood group antigens.
Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo.
Autoimmune hematological disorders.
Drew Provan and John W. Semple.
Molecular therapeutics in hematology: gene therapy.
William M. McKillop and Jeffrey A. Medin.
Pharmacogenomics.
Leo Kager and William E. Evans.
Cancer stem cells.
Sara Ali and Dominique Bonnet.
CAR- T cell therapy.
Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan.
Molecular basis of transplantation.
Pramila Krishnamurthy, Victoria Potter and Francesco Dazzi.
Index