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The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
In Vivo Non-linear Optical Microscopy as a Multidimensional​ Approach to Decipher Sensory Coding
An Open Science Model to Accelerate the Generation, Implementation and Distribution of Optogenetics and Viral Tools
Vagal Neuroinflammatio​n Accompanying Respiratory Viral Infection:​ An Overview of Mechanisms and Possible Clinical Significance
Stress-Induced Visceral Analgesia:​ Concept and Pathways
Evidence of Early Life Stress Exposure and Epigenetic Modifications in Functional Chronic Pain Disorders
Epigenetic Regulation of Stress-Induced Visceral Pain
The Biomechanics of Distal Colon and Rectum and Its Relevance to Visceral Pain
Visceral Nociception in Gastrointestinal​ Disease
Epithelial-Neuronal Communication in Visceral Pain
Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome
A Fentanyl Analogue That Activates u-Opioid Receptors in Acidified Tissues Inhibits Colitis Pain without Opioid Side Effects
Signalling in the Gut
Translating Colonic Sensory Afferent Peripheral Mechanosensitivi​ty into the Spinal Cord Dorsal Horn
Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity​
Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain
Pre-clinical Models of Endometriosis:​ A Focus on Chronic Pain
Spinal Afferent Innervation of the Uterus
Post-Infectious Bladder Hypersensitivity​ in the Development of Interstitial Cystitis/​Bladder Pain Syndrome (IC/​BPS)