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This book provides an overview of the fundamentals of tumor biology and the influence of various biologic factors, including inhomogeneity of cancer cells, microenvironment, and host factors, on the design of therapeutic strategies and the outcome of established and emerging treatments. Particular attention is devoted to multidisciplinary combined modality therapy. The topics reviewed include tumorigenesis, cell proliferation, angiogenesis, physiology of malignant tissues, adhesion and invasion, development of metastases, and the role of the immune system in cancer development. Subsequent chapters focus on cancer prevention, detection, and treatment. The principles of chemotherapy, radiotherapy, and molecularly targeted therapy are discussed, treatment resistance is explained, and strategies for rational combinations are provided, including the design of translational studies. Furthermore, the principles and clinical implications of new diagnostic and therapeutic approaches, such as gene expression profiling, gene transfer and silencing, proteomics, and molecular imaging, are presented. The chapters in this book have been written by an outstanding group of basic scientists, clinical researchers, and cancer professionals with long experience in the field. Their aim is to educate and inspire all those who devote most of their work to research into cancer and its treatment.
Front Matter
Tumorigenesis
Tumor Growth and Cell Proliferation
Tumor Angiogenesis
Pathophysiology of Solid Tumors
Adhesion, Invasion, Integrins, and Beyond
The Biology of Cancer Metastasis
Role of the Immune System in Cancer Development and Therapeutic Implications
Tumor Detection by Biological Markers
Tumor Imaging with Special Emphasis on the Role of Positron Emission Tomography in Radiation Treatment Planning
Quantitative Cell Kill of Radio- and Chemotherapy
The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy
Target-Based Interventions to Treat Radiation-Induced Lung Injury
Mechanisms of Treatment Resistance: Molecular and Clinical Examples for Radio- and Chemotherapy
DNA Repair and Cell Cycle Regulation After Ionizing Irradiation
Physiological Mechanisms of Treatment Resistance
Influence of Time Factor and Repopulation on Treatment Resistance
Molecular Tools, Expression Profiling
Strategies of Gene Transfer and Silencing, and Technical Considerations
Tumor Biology’s Impact on Clinical Cure Rates
Dose-Escalated High-Precision Radiotherapy: a Method to Overcome Variations in Biology and Radiosensitivity Limiting the Success of Conventional Approaches?
Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome
Back Matter