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This book provides an overview of planning and examining the methodology, analytic issues, primary and secondary endpoints and outcomes in headache trials. Throughout the book, guidance on how to design a high quality study and how to evaluate which study has relevant scientific qualification is discussed in detail. Clinical scales and patient related outcome measures (PROMs) to exclude secondary headaches, to diagnose primary headache disorders, to evaluate patients’ health-related quality of life, to detect psychiatric comorbidities, to assess patients’ headache-related disability and to monitor patients’ treatment optimization are clearly and concisely outlined in the chapters. Clinical Scales for Headache Disorders highlights the components for planning an effective headache study including interpretation of primary and secondary endpoints, common clinical scales, PROMs and their clinical reliability and validation. Both clinicians and researchers will find this book to be a useful tool for their medical and academic practices on headache and migraine.
What Is the Best Methodology for Headache or Migraine Research?​
Clinical Scales for Headache and Migraine
Reliability and Validity of Clinical Scales Measurement
Patient Reported Outcome Measures (PROMs) in Migraine and Headache
Measuring Pain Intensity in Headache Trials
Clinical Instruments for Diagnosing and Screening of Headache and Migraine
Clinical Instruments for Disability, Impact and Burden in Headache and Migraine
Patient-Reported Outcomes in Migraine and Cluster Headache
Clinical Scales for Psychiatric Comorbidities and Cognitive Processes in Headache and Migraine
Clinical Instruments for Treatment Monitoring and Optimization in Headache and Migraine
Other Questionnaires We Don’t Want to Miss in Headache Studies
Clinical Scales for Special Groups