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This book offers an alternative framework for the creation and evolution of local innovation and entrepreneurship ecosystems in which the central and operational role is led by the university through an Entity that Operates the Ecosystem (EOE). It explains how the university, industry and government actors interact to create ecosystems and how said ecosystems promote the growth and development of local start-ups. It provides researchers, scholars, academics and practitioners with a guide to the construction of innovation and entrepreneurship ecosystems and offers tools to assist in the creation of enterprises from entrepreneurial ideas