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Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.
Introduction on translational autoimmunity: From bench to bedside
Autophagy in autoimmunity
Immunometabolism and autoimmunity
T cell recognition of neoepitopes in autoimmunity
Role of Th1 and Th2 in autoimmunity
Role of Th17 cell in tissue inflammation and organ-specific autoimmunity
Peptide editing and its modulation in CD4   T cell tolerance to self
Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades
The role of type III interferons in systemic autoimmune diseases
Regulation of immunological tolerance and human autoimmunity by NF- κ B
Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases
Human leukocyte antigen and autoimmunity
HLA-G-mediated immunological tolerance and autoimmunity
The immune system and the microbiota: The two sides of mucosal tolerance
Role of free radicals in autoimmune diseases
Immunological tolerance and autoimmunity
Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases