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Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering.It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application.
Strategies to improve the expression and solubility of recombinant proteins in E. coli
Advances in heterologous protein expression strategies in yeast and insect systems
Methods for transient expression and purification of monoclonal antibodies in mammalian cells
Methods for recombinant production and purification of intrinsically disordered proteins
Methods to determine the oligomeric structure of proteins
Multimodal methods to study protein aggregation and fibrillation
Experimental methods to study the thermodynamics of protein–protein interactions
Experimental methods to study the kinetics of protein–protein interactions
Computational techniques for studying protein-protein interactions
Experimental methods to study protein–nucleic acid interactions
Advanced computational tools for quantitative analysis of protein–nucleic acid interfaces
Experimental techniques to study protein dynamics and conformations
Computational techniques to study protein dynamics and conformations
Application of circular dichroism spectroscopy in studying protein folding, stability, and interaction
Studying protein-folding dynamics using single-molecule fluorescence methods
Advances in liquid-state NMR spectroscopy to study the structure, function, and dynamics of biomacromolecules
In-cell NMR spectroscopy: A tool to study cellular structure biology
Current trends in membrane protein crystallography
Advances in sample preparation and data processing for single-particle cryo-electron microscopy
Advanced mass spectrometry-based methods for protein molecular-structural biologists