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Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections. Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences.
Quandary of antibiotics and multidrug resistance development: a molecular genetics-based dilemma
Antimicrobial peptides and their potent mechanism of action
Biosynthesis of lantibiotics
Development of recombinant lantibiotics and their potent uses
Mechanism of action of the lantibiotics on the multidrug-resistant organisms
Lantibiotics, its role in the meat and poultry industry
Application of lantibiotics in canned food preservation
Lantibiotics and its role in dairy product preservation
In vitro studies on a natural lantibiotic: paenibacillin
Lantibiotics in antifungal therapy: a futuristic approach
In silico studies of interaction of lantibiotics with virulent proteins
Insights at the atomistic resolution of lantibiotics using multiscale simulations
Immunogenicity studies on lantibiotics
Case studies: application of lantibiotics as novel drugs
Recent updates in understanding of molecular genetics of lantibiotics production
Methods for identification of the modes of action of lantibiotics
Computational modeling for exploring the therapeutic repertoire of lantibiotics
Combinations of nanobiomolecules as next-generation antimicrobial agents
Lantibiotics: the way forward for clinical trials and clinical approval process
Properties, classification and applications of lantibiotics from Gram-positive bacteria
Lantibiotics production—optimization and scale-up research: cutting edge and challenges
Production and optimization of lantibiotics
Analytical techniques in identifying and purifying the proteins