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Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.
Polyphenols and Flavonoids: Chemical, Pharmacological and Therapeutic Aspects
Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases
Biological Activities of Synthetic Derivatives of Xanthones: An Update (2016-2020)
Combretastatin Derivatives as Tubulin Inhibitors: A Fascinating Journey from Nature to Drug Discovery Strategies
Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents
In Silico Approaches to Naturally Existing Chalcones and Flavonoids on Mao Inhibitory Action: A Boon to CNS Drug Discovery
Lignins and Lignans – Recent Developments and Trends Regarding their Pharmaceutical Properties
Semisynthetic Resveratrol-derived Systems: A Synergism between Nature and Organic Synthesis
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
Coumarins as Carbonic Anhydrase Inhibitors
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
The Role of Flavonoids and other Selected (Poly) Phenols in Cancer Prevention and Therapy: A Focus on Epigenetics