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This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.
Drug Repurposing: An Advance Way to Traditional Drug Discovery
Drug Polypharmacology Toward Drug Repurposing
Pharmacovigilance-Based Drug Repurposing
In Silico Analysis of Cellular Interactors of PQBP1 for Potential Drug Repurposing
Drug Repurposing Opportunities in Cancer
Repurposing of Flavonoids as Promising Phytochemicals for the Treatment of Lung Carcinoma
Targeted Therapies Used in the Treatment of Non–Small-Cell Lung Cancer: An Overview
Drug Repurposing in Cancer
Targeting the Ubiquitin Machinery for Cancer Therapeutics
Repurposing of Serotonin Pathway Influencing Drugs for Potential Cancer Therapy and Antimicrobial Functions
Drug Repurposing for Hematological Malignancies
Drug Repurposing for, ENT and Head and Neck, Infectious and Oncologic Diseases: Current Practices and Future Possibilities
Repurposing of Immunomodulators for the Treatment of Cancer with QSAR Approaches
Reverse Translational Approach in Repurposing of Drugs for Anticancer Therapy
Therapeutic Targeting of Antineoplastic Drugs in Alzheimer’s Disease: Discovered in Repurposed Agents
Repurposing of Drugs for the Treatment of Microbial Diseases
Repurposing Anti-inflammatory Agents in the Potential Treatment of SARS-COV-2 Infection
Repurposing Drugs for Viruses and Cancer: A Novel Drug Repositioning Strategy for COVID-19
Drug Repurposing for COVID-19 Therapy: Pipeline, Current Status and Challenges
2-Deoxy-d-Glucose: A Repurposed Drug for COVID-19 Treatment
Repurposing Methylene Blue for the Management of COVID-19: Prospects, Paradox, and Perspective
Drug Repurposing in COVID-19 and Cancer: How Far Have We Come?
Repurposing of Doxycycline to Attenuate Influenza Virus Pathogenesis Via Inhibition of Matrix Metalloproteinases in Neutrophils
Therapeutic Repurposing Approach: New Opportunity for Developing Drugs Against COVID-19
Repurposing of Therapeutic Approaches for the Treatment of Vitiligo
Emerging Infections and Their Management
Repurposing of Minocycline, a Tetracycline Antibiotic, for Neurodegenerative Disorders