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This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&ampD has become one of the critical departments for pharmaceutical companies.
Features:
This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
Promotes an industrial mindset concerning safety and commercial viability when developing methods.
The author discusses development strategies with case studies and experimental procedures.
Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
Addresses more common process issues such as safety, cost, robustness, and environmental impact.
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
Reaction Solvent Selection
Reagent Selection
Various Reagent Surrogates
Modes of Reagent Addition: Control of Impurity Formation
Process Optimization with Additives
Process Optimization of Catalytic Reactions
Process Optimization of Problematic Reactions
Hazards of Oxidation and Reduction Reactions
Other Hazardous Reactions
Hazardous Reagents
Grignard Reagent and Related Reactions
Challenging Reaction Intermediates
Protecting Groups
Telescope Approach
Design of New Synthetic Route
Stereochemistry
Various Quenching Strategies
Various Isolation and Purification Strategies
Methods for Residual Metal Removal
Methods for Impurity Removal
Pharmaceutical Salts
Solid Form