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This book presents some of the most popular commercial steady-state process simulation software in the market. It is believed that this will be a good selflearning guide for students and working professionals in learning process simulation software, as well as for university instructors who conduct lectures on process simulation. Even though the chapters are interconnected, they are mostly written independently this allows readers to read each chapter without having to read the preceding chapters. Note, however, that the four chapters in Part 1 of the book serve as important guide on the various basic principles behind all commercial simulation software, e.g., physical properties estimation (thermodynamic models), new component registration, recycle stream simulation, etc. Readers are encouraged to read these chapters before proceeding to other parts of the book. This is particularly important for novice in process simulation. Parts 2-5 of the book cover four different families of commercial software in the market, i.e., UniSim Design, Symmetry, SuperPro Designer, and AspenONE Engineering. Each of these software has an introductory chapter (with step-by-step guide) to allow new users in mastering the usage of the software, before going into advanced topics. Table 1 shows the level of difficulties for all chapters in this book, in which the readers may refer to in selecting the topic for reading. Apart from basic simulation knowledge and the use of simulation tools in designing various production processes (e.g., n-Octane, bio-jet fuel intermediate, citric acid, diethyl carbonate, etc.), several advanced topics on process optimization (e.g., heating medium systems for offshore platform, natural gas dehydration) are also included in this book. Apart from steady-state modeling, chapters on dynamic simulation and process controllability are also covered. It is hoped that this book will serve as a useful guide for a good learning experience in process simulation knowledge. Have fun in your simulation exercises!