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This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”.
Introduction
What Is Epigenomics?
Methods and Applications of Epigenomics
Molecular Elements of Epigenomics
The Structure of Chromatin
DNA Methylation
The Histone Code
Chromatin Modifiers
Chromatin Remodelers and Organizers
Impact of Epigenomics in Health and Disease
Embryogenesis and Cellular Differentiation
Population Epigenomics and Aging
Cancer Epigenomics
Neuroepigenetics
Epigenomics of Immune Function
Nutritional Epigenomics