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This book provides a systematic review of the development, function, and patho-physiologic role of plasmacytoid dendritic cells (pDCs) in humans. The chapters of the book discuss the origin and discovery, hematopoietic development as well as molecular regulation of pDCs in the context of immune activation as well as immune tolerance. It also discusses the role of pDCs in human diseases, including infections, autoimmune/inflammatory diseases, cancers and metabolic disorders, and opportunities for pDC‐targeting therapies in these varied clinical contexts.
Discovery of a New Dendritic Cell Subset
Origin and Transcriptional Identity of Plasmacytoid Dendritic Cells
Activation and Functions of Plasmacytoid Dendritic Cells
Plasmacytoid Dendritic Cells and Infections
Plasmacytoid Dendritic Cells in Autoimmunity
Plasmacytoid Dendritic Cells and Metabolic Disorders
Tolerogenic Functions of Plasmacytoid Dendritic Cells
Plasmacytoid Dendritic Cells and Cancer
Therapeutic Targeting of Plasmacytoid Dendritic Cells