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Despite the lack of guidance available for practitioners, extensive polypharmacy has become the primary method of treating patients with severe and chronic mood, anxiety, psychotic or behavioral disorders. This ground-breaking new book provides an overview of psychopharmacology knowledge and decision-making strategies, integrating findings from evidence-based trials with real-world clinical presentations. It adopts the approach and mind-set of a clinical investigator and reveals how prescribers can practice 'bespoke psychopharmacology', tailoring care to the individualized needs of patients. Practitioners at all levels of expertise will enhance their ability to devise rationale-based treatments, targeting manifestations of dysfunctional neural circuitry and dimensions of psychopathology that cut across conventional psychiatric diagnoses. Presented in a user-friendly, practical, full-colour layout and incorporating summary tables, bullet points, and illustrative case vignettes, it is an invaluable guide for all healthcare professionals prescribing psychotropic medications, including psychiatry specialists, primary care physicians, and advanced practice registered nurses.
General Principles
Core Concepts of Good Psychopharmacology
Targets of Treatment: Categories versus Dimensions of Psychopathology
Interpreting and Using the Literature: Integrating Evidence-Based Trials with Real-World Practice
Placebo and Nocebo Effects
Tailoring the Fit: Moderators and Mediators of Treatment Outcome
Complex Regimens and Rationale-Based Combination Drug Therapies
Laboratory Values and Psychiatric Symptoms: What to Measure, What Not to Measure, and What to Do With The Results
Pharmacogenetics: When Relevant, When Not
Cross-tapering and the Logistics of Drug Discontinuation
Managing Major Adverse Drug Effects: When to Avoid, Switch, or Treat Through
Novel Drug Therapeutics: Nutraceuticals, Steroids, Probiotics, and Other Dietary Supplements
Human Diversity and Considerations in Special Populations
Targets of Pharmacotherapy
Disordered Mood and Affect
Disorders of Impulsivity, Compulsivity, and Aggression
Psychosis
Deficit States and Negative Symptoms
Anxiety
Addiction and the Reward Pathway
Trauma and Post-traumatic Stress Disorder
Personality Disorders and Traits
Cognition
Putting it All Together