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Power reduction is a central pnonty in battery-powered medical implantable devices, particularly pacemakers, to either increase battery lifetime or decrease size using a smaller battery. This book proposes new techniques for the reduction of power consumption in analog integrated circuits applied in pacemakers. Its main case of study is the pacemaker sense channel, which is representative of a broader class of biomedical circuits aimed at qualitatively detecting biological signals. The book is expected to be useful for researchers, postgraduate students and designers in both the areas of analog integrated circuits and implantable medical devices. The basis of this text was written as a Ph.D. thesis at the Universite Catholique de Louvain, Louvain-la-Neuve, Belgium. Part of the work was developed at the lnstituto de Ingenierfa Electrica, Universidad de la Republica, Montevideo, Uruguay. Concurrently with the development of the thesis, an industrial integrated circuit for pacemakers was designed for CCC S.A, Uruguay, a pacemaker factory. In this and subsequent projects with CCC S.A. the pacemaker appeared as an example of choice for the analysis of the impact of application of SOl technology and power-aware design techniques. The book contains six chapters. The first and second chapters are a tutorial presentation on implantable medical devices and pacemakers from the circuit designer point of view. This is illustrated by the requirements and solutions applied in our implementation of an industrial IC for pacemakers. Therefrom, the book discusses the means for reduction of power consumption at three levels: integration technology, power-oriented analytical synthesis procedures and circuit architecture