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This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.
Basic Concepts of Design of Peptide-Based Therapeutics
Peptide Synthesis: Methods and Protocols
Computational Methods for Peptide Macrocycle Drug Design
Strategies to Optimize Peptide Stability and Prolong Half-Life
Therapeutic Peptide Delivery: Fundamentals, Formulations, and Recent Advances
Liposome Nanocarriers for Peptide Drug Delivery
Peptides and Their Delivery to the Brain
Emerging Peptide Drug Modalities for Intracellular Target Space
Regulatory Issues for Peptide Drugs