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This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures.
RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.
Generating New Specific RNA Interaction Interfaces Using C-Loops
Specific RNA Self-Assembly with Minimal Paranemic Motifs
In vitro Assembly of Cubic RNA-Based Scaffolds Designed in silico
Self-Assembling RNA Nanorings Based on RNAI/II Inverse Kissing Complexes
Multistrand RNA Secondary Structure Prediction and Nanostructure Design Including Pseudoknots
Computational and Experimental Characterization of RNA Cubic Nanoscaffolds
In silico Design and Enzymatic Synthesis of Functional RNA Nanoparticles
Ring Catalog: A Resource for Designing Self-Assembling RNA Nanostructures
Programmable RNA Microstructures for Coordinated Delivery of siRNAs †
Versatile RNA Tetra-U Helix Linking Motif as a Toolkit for Nucleic Acid Nanotechnology
Functional RNA Nanoparticles and Their Delivery
Design and Self-Assembly of siRNA-Functionalized RNA Nanoparticles for Use in Automated Nanomedicine
Co-transcriptional Assembly of Chemically Modified RNA Nanoparticles Functionalized with siRNAs
Multifunctional RNA Nanoparticles
Oxime Ether Lipids Containing Hydroxylated Head Groups are More Superior siRNA Delivery Agents Than Their Bolaamphiphiles as Carriers for siRNA Delivery: From Chemical Syntheses to Practical Applications
Magnetic Nanoparticles Loaded with Functional RNA Nanoparticles,
ByMelissa Cruz-Acuña, Justin R. Halman, Kirill A. Afonin, Jon Dobson, Carlos Rinaldi
Multimodal Polysilsesquioxane Nanoparticles for Combinatorial Therapy and Gene Delivery in Triple-Negative Breast Cancer
A Cationic Amphiphilic Co-polymer as a Carrier of Nucleic Acid Nanoparticles (NANPs) for Controlled Gene Silencing, Immunostimulation, and Biodistribution
Cellular Delivery of RNA Nanoparticles
Exosome Mediated Delivery of Functional Nucleic Acid Nanoparticles (NANPs)
Combination of Nucleic Acid and Mesoporous Silica Nanoparticles: Optimization and Therapeutic Performance in vitro
Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology
Dynamic Nucleic Acid Nanoparticles
Activation of Different Split Functionalities on Re-association of RNA–DNA Hybrids
Co-transcriptional Production of RNA–DNA Hybrids for Simultaneous Release of Multiple Split Functionalities
Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches
The Use of Minimal RNA Toeholds to Trigger the Activation of Multiple Functionalities
Functionally-Interdependent Shape-Switching Nanoparticles with Controllable Properties
Dynamic Behavior of RNA Nanoparticles Analyzed by AFM on a Mica/Air Interface
Broccoli Fluorets: Split Aptamers as a User-Friendly Fluorescent Toolkit for Dynamic RNA Nanotechnology
Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology
Immunomodulation with NANPs
Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling
Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles
RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition
RNA–DNA Fibers and Polygons with Controlled Immunorecognition Activate RNAi, FRET and Transcriptional Regulation of NF-κB in Human Cells
Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells
Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior
Innate Immune Responses Triggered by Nucleic Acids Inspire the Design of Immunomodulatory Nucleic Acid Nanoparticles (NANPs)
Retinoic Acid Inducible Gene-I Mediated Detection of Bacterial Nucleic Acids in Human Microglial Cells
Use of Human Peripheral Blood Mononuclear Cells to Define Immunological Properties of Nucleic Acid Nanoparticles
The Immunorecognition, Subcellular Compartmentalization, and Physicochemical Properties of Nucleic Acid Nanoparticles can be Controlled by Composition Modification