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This new book provides comprehensive coverage of the subjects of deuterium oxide and deuteration in biosciences, with an emphasis on the biochemical, biomedical, and pharmacological aspects. Deuterium oxide and deuteration effects also offer various implications for health-related issues, including diseases, vaccines and drugs. Organized in six sections, the chapter topics include the role of regular and heavy water in biosciences, and their implications to biomolecules, biochemical processes, health-related research, and pharmacology.Due to the broad scope, the book may be used as a supplemental text for upper-level undergraduate and graduate courses in the related fields of biochemistry, biology, biomedical sciences, biophysics, and pharmacology. Researchers and pharmaceutical industry professionals will also find the content useful in order to gain knowledge and better understand the implications of deuterium oxide and deuteration research.
Roles of Regular and Heavy Water in Biosciences
Overview: Background and Applications
Characteristics of Deuterium Oxide Versus Hydrogen Oxide
Molecular Interactions of Deuterium Versus Hydrogen Oxide
Deuterium Bonding Versus Hydrogen Bonding
Hydrophobic Interaction in D2O Versus H2O
Implications of Deuterium Oxide and Deuteration in Biological Systems
Deuterium Oxide and Deuteration Effects on Biomolecules
Effects of D2O and Deuteration on Biomembranes
Applications of D2O and Deuteration to Biochemical Reactions
Biochemical Effects of Deuterium Oxide and Deuteration
Physical Methods for Investigating D2O and Deuteration Effects
Exploration of Deuterium Oxide and Deuteration in Health-Related Research
Living Cells Grown in Deuterium Oxide for Deuteration
Deuterium Oxide and Deuteration Effects on Health Issues
Applications of Deuterium Oxide and Deuteration to Pharmacology
Deuterium Oxide Effects on Thermostability of Vaccines
Deuterium Oxide and Deuteration Effects on Pharmacology