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Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine.
Key Features
Provides the first summary on this important topic
Reviews redox-dependent development of model organisms and single organs
Highlights the redox-regulated pathways important for differentiation processes
Illustrates the potential of redox medicine
Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration
Written by leading experts in the field
Preface
Contributors
Introduction
Thiol Redox Regulation: A Brief Historical Overview
Development of (In)Vertebrate Model Organisms
Redox Regulation of Plant Development
Thiol-Disulphide Redox Signalling/Control during the Life Cycle of Pathogenic Trypanosomatids
Redox Regulation during Zebrafish Development
Development/Differentiation of Vertebrate Tissues
The Differential Roles of NOX-Derived Reactive Oxygen Species in Development, Function, and Dysfunction of the Nervous System
H2O2 in Morphogenesis and Regeneration
Protein S-Nitrosylation in Neuronal Development
NADPH Oxidases in Bone Cells
Signaling Pathways during Differentiation and Longevity
Identification of Redox-Regulated Pathways via Redox Proteomics
Glutathione during Development
Roles of NRF2 in Quiescence and Differentiation
Role of Iron in Cell Differentiation
Redox Regulation of Cytoskeletal Dynamics
At the Interface between Metabolism and Redox Regulation: Sirtuin 1 as Checkpoint for Neurogenesis and Longevity
Roles of Hydrogen Peroxide and Peroxiredoxin in the Yeast Replicative Aging Model of Aging and Age-Related Disease
Supersulfide-Mediated Signaling during Differentiation and De-Differentiation
Supersulfide-Mediated Signaling during Differentiation and De-Differentiation
Selenoproteins during Cancer Development and Progression
Hypoxia and Regulation of Cancer Stem Cells
Redox Medicine
Redox Homeostasis and Diseases of Cellular Differentiation
Gas Plasma: Innovative Cancer Therapy and Cellular Differentiation in Immuno-Oncology
Nutrition-Based Redox Regulation in Fish: Implications for Growth, Development, Health, and Flesh Quality
Index