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This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the ‘One Health’ approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics.
Introductory Chapter
Quest for Alternatives to Antibiotics:​ An Urgent Need of the Twenty-First Century
Natural Alternative Approaches
Phytochemicals as Antibacterial Agents:​ Current Status and Future Perspective
Quorum Quenching Enzymes:​ A Potent Alternative to Conventional Antibiotics
Antibodies as Antibacterial Molecules:​ The New Era of Antibody-Mediated Immunity
Phage Therapy:​ Genomics to Applications and Future Prospects
Alternatives to Antibiotics in Animal Farming
Chemical Alternative Approaches
Metal-Catalyzed Synthesis of β-Lactam Antibiotics
Upgrading the Antibiotic Arsenal Against Gram-Positive Bacteria:​ Chemical Modifications of Vancomycin
Heterocyclic Scaffolds in Novel Synthetic Antibacterial Agents
Antibacterial Metal-Organic Frameworks
Cationic Amphiphilic Molecules as Bactericidal Agents
Nanomaterial Based Alternative Approach
Polymeric Nanoparticles and Nanocomposites as Antibacterial Agents
Metallic Nanoparticles and Their Composites as Alternative Antibacterial Therapeutics
Carbon Nanoparticles as the Next-Generation Antimicrobial Agents
Dendrimeric Entities as Chemical Alternatives Toward Antimicrobial Therapy
Ionic Liquids, Ionic Liquid Nanoparticles, and Nanocomposites:​ The Future Antibiotics
Probiotics and Other Alternative Approaches
Prebiotic Immunomodulators​ to Enhance Mucosal Immunity and to Reduce Mass Use of Antibiotics
The Use of Probiotics, Prebiotics, and Synbiotics as an Alternative to Antibiotics
The Implication of Antimicrobial Peptides Against Bacteria and Their Clinical Aspects
Development of Probiotics for Helicobacter pylori Infection Management
Implications of Probiotics in Management of Bacterial Infections
Nanocarriers for the Molecular Targeting of Pathogenic Bacteria