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The Origins of Schizophrenia synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments in a comprehensive volume, this collection by world-renowned investigators answers a pressing need for balanced, thorough information, while pointing to future directions in research and interdisciplinary collaboration.
The book, featuring a foreword by Robert Freedman, M.D., thoroughly examines these topics from the vantage points of epidemiologic, clinical, and basic neuroscience approaches, making it an essential resource for researchers in psychiatry, psychology, and neuroscience and for clinical mental health professionals.
Foreword
Acknowledgments
Introduction
Overview
Clinical Research on Risk Factors for Schizophrenia
Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia
Maternal Infection and Schizophrenia
Prenatal Nutrition and the Etiology of Schizophrenia
Obstetric Complications and Schizophrenia: Historical Overview and New Directions
Maternal Stress During Pregnancy and Schizophrenia
Advancing Paternal Age and the Risk for Schizophrenia
Cannabis Use as a Component Cause of Schizophrenia
Genetics and Epigenetics
Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies?
Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation
The Epigenetics of Schizophrenia
Preclinical Research on Etiologies of Schizophrenia
Animal Models of Environmental Factors and Schizophrenia
Animal Models of the Maternal Infection Risk Factor for Schizophrenia
Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia
Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia
Animal Models of the Maternal Stress Risk Factor for Schizophrenia
Animal Models of Genetic Factors and Schizophrenia
Disc1: A New Paradigm for Schizophrenia and Biological Psychiatry
Mutant Models of Nrg1 and ErB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia
Contributors
Index