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This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics.
Small Leucine-Rich Proteoglycans Regulate Cancer Cell Growth, Apoptosis, and Associated Inflammation
The Role of Decorin in Cancer
The Mystery of Syndecan-1 in Tumor Development and Progression
Syndecan-2 Biology and Its Role in Colorectal Carcinoma
Versican in Tumor Progression, Tumor–Host Interactions, and Cancer Immunotherapy
Circulating Proteoglycans/​Glycosaminoglyca​ns as Cancer Biomarkers
Hyaluronan in the Extracellular Matrix of Hematological and Solid Tumors.​ Its Biological Effects
Heparanase:​ A Paramount Enzyme for Cancer Initiation, Progression, and Metastasis
Laminins and Matrix Metalloproteinas​es Connection:​ A Subtle Relationship That Can Go Wrong in a Tumor Context, Particularly If CD44 Gets Involved
Basement Membrane, Collagen, and Fibronectin:​ Physical Interactions with Cancer Cells
Integrins in Cancer:​ Refocusing on the Tumor Microenvironment​
Adipose Compounds in Breast Tumor Extracellular Matrix
Extracellular Matrix as a Metabolic Niche in Cancer
The Role of Inflammatory Cells in Tumor Angiogenesis
Cancer Angiogenesis and Its Master Regulator Perlecan
The microRNA-Extracellular Matrix Interplay in Breast Cancer
The Impact of the Extracellular Matrix on Immunotherapy Success
Exploiting Hyaluronan-CD44 Network in Tumor Therapy