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Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
The Foundation of IBD Genetics, Human and Animal Studies
A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges
Genetic Epidemiology of Infl ammatory Bowel Disease, Early Twin and Family Studies
Insights from Recent Advances in Animal Models of Infl ammatory Bowel Disease
The Genetic and Molecular Makeup of Infl ammatory Bowel Disease
Complex Disease Genes and Their Discovery
The Genetics of Crohn’s Disease
Genetics of Ulcerative Colitis
Genetic Overlap Between Infl ammatory Bowel Disease and Other Diseases
Molecular Profi ling of IBD Subtypes/Response to Therapy
Epigenetics of Infl ammatory Bowel Disease
Pathogenetic Pathways in Infl ammatory Bowel Disease
Nod1 and Nod2 and the Immune Response to Bacteria
The IL23-Th17 Axis in Intestinal Infl ammation
Infl ammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
The Epithelial Barrier
Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli”
Cytokines in Infl ammatory Bowel Disease
Concluding Remarks and Future Perspectives
Towards Personalized Therapy in Infl ammatory Bowel Disease