In this prequel re-telling of the famous 1979-1985 TV series of the same name, the teenage mischievous Duke boys, cousins Bo and Luke (Jonathan Bennett and Randy Wayne), are arrested for reckless driving and possession of illegal fireworks. They are sent to live with their Uncle Jesse (Willie Nelson) at his farm in rural Hazzard County in an unnamed southwestern state. Bo and Luke's orphaned dowdy cousin Daisy (April Scott) soon joins them hoping to find a place in her life. Jesse is also a moonshiner who struggles to make ends meet and soon employs a willing Bo and Luke to be his runners to deliver his 'special' White Lighting whiskey to all parts of the county after observing their driving skills using a fixed-up orange-painted 1969 Dodge Charger which they named 'The General Lee'. But it doesn't take long for Bo and Luke to find a worthy opponent in the form of the cigar-chomping J.D. 'Boss' Hogg (Christopher McDonald), the corrupt city commissioner of the nearby small town and county seat capital of Hazzard who makes it his mission to stop the Duke Boys in any way possible.
Teenaged cousins Bo and Luke Duke spend their first few weeks in Hazzard County getting into trouble running outlawed liquor in order to save their Uncle Jesse's farm.
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