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This book is a toolkit for teaching a course on the pathophysiology of disease and how the most widely utilized laboratory tests can be used to diagnose these conditions. Tests for the major common diseases are presented by organ system. It is also a study guide for students and trainees as they prepare for their respective board examinations. Each topic includes succinct text focusing on a disease topic along with a set of PowerPoint lecture slides and clinical cases (with answers). The toolkit also contains instructions for preparing the teaching laboratories for the course, a comprehensive list of differential diagnoses for the most frequent clinical chemistry abnormalities, discussion of selected cases taken by pathology residents while on night-call, and quiz questions (with answers). Analytical methodology is not presented unless it is important in understanding the test. This third edition includes updated material on tumor markers, Alzheimer’s disease markers, markers for pre-eclampsia, additional drugs for which therapeutic monitoring is available, and biomarkers for ethanol abuse, among others.
The comprehensive toolkit is the result of more than 40 years of teaching an introductory course in clinical chemistry to second-year medical students at the University of California San Diego. Elements of this book have also been used in teaching UC San Diego clinical laboratory scientist training program students, pharmacy students, clinical chemistry postdoctoral fellows, and pathology residents. This work has been previously published in two editions (2017 and 2021) by the American Society for Clinical Pathology (ASCP) Press under the title “Practical Laboratory Diagnosis of Disease: Clinical Chemistry.”
Clinical Laboratory Statistics
The Effects of Hemolysis, Icterus, Lipemia, Refrigeration, Diurnal Variation, and Drugs on Laboratory Tests Pediatric Clinical Chemistry
The Laboratory Diagnosis of Myocardial Infarction and Heart Failure
The Laboratory Diagnosis of Gastrointestinal Disease
The Laboratory Diagnosis of Renal Disease
Urinalysis
Laboratory Examination of Body Fluids
The Laboratory Diagnosis of Electrolyte and Acid-Base Disturbances
The Laboratory Diagnosis of Calcium, Phosphorus, and Magnesium Disorders
The Laboratory Diagnosis of Iron Disorders
The Laboratory Diagnosis of Pancreatic Disease
The Laboratory Diagnosis of Liver Disease
Tumor Markers
The Laboratory Diagnosis of Protein Abnormalities
Reproductive Clinical Chemistry
Clinical Toxicology
Therapeutic Drug Monitoring
The Laboratory Diagnosis of Thyroid Disease
The Laboratory Diagnosis of Diabetes Mellitus
The Laboratory Diagnosis of Adrenocortical Disease
The Laboratory Diagnosis of Lipid Disorders