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This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles
The Tumor Microenvironment​
Methods to Formulate Polymeric Nanoparticles
Natural Polymers-Based Nanoparticles Targeted to Solid Tumors
Optimization of Physicochemical Properties of Polymeric Nanoparticles for Targeting Solid Tumors
Passive and Active Targeting for Solid Tumors
Polymeric Nanoparticles to Entrap Natural Drugs for Cancer Therapy
Polymeric Nanoparticles that Entrap Drug Combinations Targeted to Solid Tumors
Ligands Specific to Over-expressed Receptors in Solid Tumors
Ligand Targeted Polymeric Nanoparticles for Cancer Chemotherapy
Polymeric Nanoparticles as Theranostics for Targeting Solid Tumors
Oral Delivery of Polymeric Nanoparticles for Solid Tumors
Polymeric Nanoparticles to Target Glioblastoma Tumors
Polymeric Nanoparticles to Target Lung Cancer
Polymer-Based Nanoplatforms for Targeting Breast Cancer
pH-Sensitive Polymeric Nanoparticles for Cancer Treatment
Polymeric Nanoplatforms for the Targeted Treatment of Prostate Cancer
Cellular Internalization and Toxicity of Polymeric Nanoparticles
Prospects and Challenges in the Treatment of Solid Tumors