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Cadherins are adhesion molecules which mediate homophilic Ca2 -dependent intercellular adhesion. They play a crucial role in tissue morphogenesis during embryonic development and in the maintenance of tissue architecture in adults. In this compilation, the authors review and discuss the structure of the cadherin-mediated junctions in seminiferous tubules and their functions in male fertility. Additionally, role of E-cadh in uterine and mammary gland homeostasis is reviewed, and the disruptive patterns of E-cadh expression in neoplastic conditions of the uterus and mammary glands in humans and domestic dogs and cats are described
Standing Out from the Crowd: Functions of T-Cadherin in Health and Disease
Abstract
Abbreviations
Cadherin Superfamily of Intercellular Adhesion Molecules
Distinguishing T-Cadherin from Other Cadherin Family Members: Structural Features
Distinguishing T-Cadherin from Other Cadherin Family Members: Signaling Partners and Heterophilic Ligands
The Nervous System
Axon Guidance
Neuropsychiatric Disorders
The Cardiovascular System
Endothelial Cells and Angiogenesis
Smooth Muscle Cells and Atherosclerosis
Vascular Insulin Resistance
Cardiomyocytes
Lung
Pancreas
Liver
Kidney
Bone and Cartilage
The Cochlea
Cancer
Cutaneous Cancer and Other Proliferative Conditions of the Skin
Breast Cancer
Prostate Cancer
Lung Cancer
Gastrointestinal Cancers
Liver Cancer
Pancreatic Cancer
Bladder Cancer
Gallblader Cancer
Gynaecologic Cancers
Head and Neck Cancer
Tumors of the Nervous System
Blood Cancers
Osteosarcoma
Pituitary Gland Tumors
Retinoblastoma
Cadherin-Mediated Cell Adhesion within the Seminiferous Tubules
Abstract
Junctional Complexes in the Seminiferous Tubules
Cadherins
Cadherin in the Junctional Complexes of the Seminiferous Tubules
Cadherins Presence in the Seminiferous Tubules
Cadherin Adaptors and Scaffold Proteins
Alternative Adaptors and Scaffolds for N-Cadherin in the Seminiferous Tubules
Junction Dynamics and Spermatogenesis
Biographical Sketch
Disruption of E-Cadherin Pattern in Uterine and Mammary Tumours
Abstract
E-Cadherin at the Core of Epithelial Adherens Junctions
E-Cadherin as a Key Modulator during Development and Neoplastic Progression
E-Cadherin Expression in Uterine Cancer
E-Cadherin in the Normal Endometrium
E-Cadherin in Endometrial Carcinomas
E-Cadherin Expression in Mammary Cancer
E-Cadherin Expression in Normal Mammary Tissues
E-Cadherin Expression in Mammary Cancer