Externally indexed torrent

If you are the original uploader, contact staff to have it moved to your account

Textbook in PDF format

This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chromothripsis: Methods and Protocols serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability.
Genesis and Impact of Chromothripsis
The Genomic Characteristics and Origin of Chromothripsis
Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
Chromothripsis and the Macroevolution Theory
The Identification of Chromothripsis
Analysis of Chromothripsis by Combined FISH and Microarray Analysis
Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
Detection of Chromothripsis in Plants
RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
The Causal Mechanisms of Chromothripsis
Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
A Role for Retrotransposons​ in Chromothripsis
Generation of Micronuclei and Detection of Chromosome Pulverization
Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
Genes, Proteins, and Biological Pathways Preventing Chromothripsis
Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
The Bioinformatic Tools for Chromothripsis Analysis
Chromothripsis Detection and Characterization​ Using the CTLPScanner Web Server
ChromothripsisDB​:​ A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
The Experimental Models
Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos
Correlative Live Imaging and Immunofluorescen​ce for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
Experimental Induction of Genome Chaos
Looking for Broken TAD Boundaries and Changes on DNA Interactions:​ Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis