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Cutaneous adverse drug reactions are common and range from the benign to those which are life-threatening. The clinical presentation of these dermatoses is varied and many may mimic common skin conditions. Consequently, diagnosis in drug-induced skin disease is challenging and the treatment considerations are complex. This book aims to bridge the divide between dermatology and allergy by providing a comprehensive review on the pathomechanisms and clinical features of cutaneous adverse drug reactions. Broken up into three distinct sections: General Considerations, Reaction Patterns, and Special Drug Categories, these chapters cover the common and rare adverse skin reactions and provide information on recent advances - particularly immunopathology and pharmacogenetics - as well as highlighting new adverse drug signals and novel therapies.Drug Eruptions is a must-have resource for dermatologists, allergists, internal physicians and general practitioners.
General Considerations
Pharmacogenetics​ of Cutaneous Adverse Drug Reactions
Mechanisms of Drug Hypersensitivity​
Histopathology of Cutaneous Adverse Drug Reactions
Skin Tests in Evaluating Drug Eruptions
In Vitro Drug Allergy Testing
Reaction Patterns
Drug-Induced Urticaria
Exanthematous Drug Eruptions
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
Acute Generalised Exanthematous Pustulosis
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Fixed Drug Eruptions and Generalized Bullous Fixed Drug Eruptions
Lichenoid Drug Eruptions
Drug-Induced Connective Tissue Disorders
Drug-Induced Vasculitis
Drug-Induced Autoimmune Bullous Diseases
Other Drug-Induced Inflammatory Skin Reactions
Drug-Induced Photosensitivity​
Drug-Induced Pruritus Without Primary Rash
Drug-Induced Nail Changes
Drug-Induced Hair Changes
Drug-Induced Pigmentary Disorders
Special Drug Categories
Immediate and Delayed Reactions to Beta-Lactams
Hypersensitivity​ Reactions to Iodinated Radiocontrast Media
Cutaneous Adverse Reactions to Biologic Agents
Cutaneous Reactions to Oncologic Targeted Therapy
Cutaneous Reactions to Oncologic Immunotherapy